Key result
AT1 stimulation increases sarcolemmal Na+/H+ exchanger activity in adult rat ventricular myocytes via ERK activation, an effect counteracted by simultaneous AT2 stimulation.
Population
Adult rat ventricular myocytes
Comparison
Angiotensin II with or without various receptor… vs Angiotensin II alone or different inhibitor…
Design
Preclinical
Authors
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AT1/AT2 balance may modulate myocyte Na/H exchange; animal data leave open relevance to human cardiac remodeling or therapy.
AT1 receptor stimulation increases Na+/H+ exchanger activity in adult rat ventricular myocytes via ERK activation, an effect that is counteracted by simultaneous AT2 receptor stimulation.
Gunasegaram et al. (1999) studied this question. Angiotensin II was evaluated on Sarcolemmal Na+/H+ exchanger activity. AT1 stimulation increases sarcolemmal Na+/H+ exchanger activity in adult rat ventricular myocytes via ERK activation, an effect counteracted by simultaneous AT2 stimulation.
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