December 7, 2001Circulation Research

Molecular Basis for Angiotensin II-Induced Increase of Chloride/Bicarbonate Exchange in the Myocardium

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Population

Adult rat heart tissue and transfected HEK293 cells

Comparison

Exposure to Angiotensin II or PKC activator PMA vs Baseline activity or mutated cells

Design

Preclinical

Authors

BÁBernardo V. ÁlvarezConsejo Nacional de Investigaciones Científicas y Técnicas JFJocelyne FujinagaUniversity of Alberta JCJoseph R. CaseyRoyal College of Surgeons in Ireland

Discussion

Member takes

Implication

May implicate AE3 Ser67 in Ang II-driven hypertrophy; hypothesis-generating and should not yet change practice.

Structured PICO

Population

Adult rat heart tissue and transfected HEK293 cells

Intervention

Exposure to Angiotensin II (500 nmol/L) or PKC activator PMA (150 nmol/L)

Comparator

Baseline activity or mutated cells (serine 67 to alanine)

Outcome

Anion transport activity (measured by changes in intracellular pH associated with bicarbonate transport)surrogate

Angiotensin II stimulates PKCepsilon to phosphorylate serine 67 of the AE3 cytoplasmic domain, increasing anion transport which may contribute to cardiac hypertrophy.

Cite This Study

Álvarez et al. (2001) studied this question.

synapsesocial.com/papers/6a70c7e3febe604dd7098c28 https://doi.org/10.1161/hh2401.101907

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Molecular Basis for Angiotensin II-Induced Increase of Chloride/Bicarbonate Exchange in the Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular Basis for Angiotensin II-Induced Increase of Chloride/Bicarbonate Exchange in the Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider