September 1, 1995Journal of Biological ChemistryOpen Access

Angiotensin II Activates the Na+/HCO3- Symport through a Phosphoinositide-independent Mechanism in Cardiac Cells

View Full Paper

Ask AI

Bookmark

Population

Cultured neonatal rat ventricular myocytes

Design

Preclinical

Authors

TKTrudy A. KohoutUniversity of North Carolina at Chapel Hill TRTerry B. RogersUniversity of Maryland, Baltimore

Discussion

Member takes

Implication

No immediate clinical implications; hypothesis-generating for AngII-AT2 pH effects in cardiac cells.

Structured PICO

Population

Cultured neonatal rat ventricular myocytes

Intervention

Angiotensin II (100 nM)

Outcome

Changes in intracellular pH (pHi)surrogate

Angiotensin II activates the Na+/HCO3- symport in cardiac cells through an AT2 receptor-mediated, phosphoinositide-independent pathway likely related to fatty acid production.

Cite This Study

Kohout et al. (1995) studied this question.

synapsesocial.com/papers/6a71f05335aa2c282ce30247 https://doi.org/10.1074/jbc.270.35.20432

View Full Paper

Ask AI

Bookmark

Angiotensin II Activates the Na+/HCO3- Symport through a Phosphoinositide-independent Mechanism in Cardiac Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Activates the Na+/HCO3- Symport through a Phosphoinositide-independent Mechanism in Cardiac Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider