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July 26, 2026ChemBioChemOpen Access

The Reality of Active Targeting in Nanomedicine: Promise Versus Performance

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Authors

FCFrancesco Cellesi

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Overview

Perspective examines the effectiveness of active targeting in nanomedicine, suggesting a need for system-level design.

Key Points

  • This work investigates the effectiveness of active targeting in nanomedicine and identifies gaps in current approaches.
  • Critically reviewed current literature on active targeting in nanomedicine.
  • Compared existing targeting methods with natural biological systems.
  • Proposed a design-by-architecture framework for improved targeting efficacy.
  • Current targeting methods often oversimplify the processes involved, neglecting key biological factors.
  • Natural targeting involves complex energy-dependent processes not replicated in many nanomedicine strategies.
  • A systems-level design incorporating spatiotemporal control and adaptive materials is essential for future advancements.

Cite This Study

Francesco Cellesi (2026) studied this question.

synapsesocial.com/papers/6a65a91fd3aea3239cd79209https://doi.org/10.1002/cbic.70475
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  1. 1Editorial: Advancements in nanomedicine for targeted cancer therapy and imaging2026
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  4. 4Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions2025 · 48 citations
  5. 5Translational Landscape of Nanopharmaceuticals: Progress and Prospects on Biomacromolecule Delivery and Active Targeting2026