What question did this study set out to answer?

To compare the efficacy and safety of mazdutide and dulaglutide in adults with type 2 diabetes mellitus.

Efficacy and safety of mazdutide vs. dulaglutide in adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

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Systematic review and meta-analysis shows enhanced blood sugar control with mazdutide in adults with T2DM, suggesting a promising new therapy.

To compare the efficacy and safety of mazdutide and dulaglutide in adults with type 2 diabetes mellitus.
Systematic review of randomized controlled trials comparing mazdutide and dulaglutide
Primary outcomes: changes in HbA1c, body weight, glycemic and weight-loss targets
Data pooled using random-effects models and evidence certainty assessed with GRADE.
Mazdutide reduced HbA1c by −0.25% and body weight by −2.97 kg compared to dulaglutide.
Higher likelihood of achieving HbA1c < 7.0% and ≥ 5% weight loss with mazdutide.
Increased gastrointestinal side effects and decreased appetite noted with mazdutide.

Hassan et al. (2026) studied this question.

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Systematic review and meta-analysis shows enhanced blood sugar control with mazdutide in adults with T2DM, suggesting a promising new therapy.