Key result
Regular physical training improved nitric oxide bioavailability in 13 of 16 studies and reduced blood pressure in 15 of 16 studies among pre-hypertensive and hypertensive individuals.
Why the study?
Physical exercise is encouraged for arterial hypertension due to cardiovascular physiological responses like nitric oxide production, but the effect of physical training on nitric oxide levels required elucidation.
Systematic Review
May support exercise for hypertension via NO; leaves open need for RCTs to guide practice.
The regular practice of physical exercise as a non-pharmacological treatment of arterial hypertension (AH) has been encouraged due to causing a series of physiological responses in the cardiovascular system, such as the production of vasoactive substances, including nitric oxide (NO). NO is a relaxation factor released by the endothelium, and the decrease in its bioavailability is related to coronary and arterial diseases, such as AH. This study aimed to perform an integrative literature review to elucidate the effect of [...]
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Facioli et al. (2021) conducted a systematic review in Arterial hypertension. Physical training vs. No exercise or baseline was evaluated on Nitric oxide (NO) levels and blood pressure. Regular physical training improved nitric oxide bioavailability in 13 of 16 studies and reduced blood pressure in 15 of 16 studies among pre-hypertensive and hypertensive individuals.
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