Key result
Chemoreceptor stimulation with hypoxic blood in the isolated carotid bifurcation of rabbits caused bradycardia mediated by vagal efferent pathways and sympathetic fibers.
Why the study?
Does carotid body chemoreceptor stimulation with hypoxic blood reduce heart rate in rabbits?
Does carotid body chemoreceptor stimulation with hypoxic blood reduce heart rate in rabbits?
Carotid body chemoreceptor stimulation by hypoxia induces bradycardia in rabbits via vagal and sympathetic pathways, a response that is modulated by ventilation.
Answers are grounded in this paper and cite their sources.
Bradycardia occurs with carotid chemoreceptor stimulation under controlled ventilation; leaves open translation to human hypoxic reflexes.
Summary The isolated carotid bifurcation regions of the rabbit were perfused with blood. Stimulation of the chemoreceptors in the carotid bodies was achieved by perfusion with hypoxic blood from a donor rabbit. Under conditions of controlled ventilation, chemoreceptor stimulation caused a slowing of the heart. This response was considerably modified by hyperventilation, either occurring spontaneously with the chemoreceptor excitation or induced artificially. The responses occurred whether the aortic depressor nerves were intact or not. The bradycardia of chemoreceptor origin was mediated both by vagal efferent pathways and by sympathetic fibres to the heart.
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Mary J. Scott (1966) studied this question. Chemoreceptor stimulation by perfusion with hypoxic blood was evaluated on Heart rate. Chemoreceptor stimulation with hypoxic blood in the isolated carotid bifurcation of rabbits caused bradycardia mediated by vagal efferent pathways and sympathetic fibers.
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