Key result
Fenugreek seed soluble dietary fiber reduces weight gain, glucose, and lipids in olanzapine-induced metabolic syndrome.
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Trigonella foenum graecum(TF) belongs to the family Fabaceae, it has been from ancient time, used as a spice and traditionally ethno pharmacological medicine for promoting digestion and reduce blood sugar levels in a diabetic patient in India. In the present study, soluble dietary fiber (SDF) was isolated from TF seeds and investigates the role of SDF of TF, against olanzapine induced metabolic complications. Metabolic syndrome was induced by oral administration of OLZ 5mg/kg in rats for 28 days. Then rats were treated with OLZ and SDFF of TF at 250 and 500mg/kg; po./day and metformin as a standard 100mg/kg; po./day. SDF of TF treatment significantly decreased body weight gain, feed and water intake, blood glucose, oral glucose tolerance test (OGTT), lipid profile, liver enzymes, uric acid and improved hemodynamic parameters, antioxidant status and reduced histopathological changes caused by OLZ treatment in rats. SDF of TF increased the satiety, suppresses appetite and improved the glucose and lipid metabolism and antioxidant potential exert the beneficial role in olanzapine induced metabolic syndrome.
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Ajay Singh Kushwah (2018) studied Olanzapine-induced metabolic syndrome. Soluble dietary fiber fraction of Trigonella foenum graecum seeds vs. Metformin 100mg/kg; po./day and unmitigated olanzapine was evaluated on Metabolic and hemodynamic parameters (body weight gain, blood glucose, lipid profile, liver enzymes, uric acid). Soluble dietary fiber of Trigonella foenum graecum seeds significantly decreased body weight gain, blood glucose, and lipid profile in rats with olanzapine-induced metabolic syndrome.
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