Evaluation of the cardioprotective role of hydroxy methylcoumarin on isoproterenol induced myocardial infarction in rats

Coumarins are the oldest class naturally occurring benzopyrene derivatives associated with remarkable pharmacological activities one of the most potent hydroxy methylcoumarin H MC shown the presence of various pharmacological activities Thus the present study aims to evaluate the cardioprotective effect of hydroxy methylcoumarin on isoproterenol ISO induced myocardial infarction in rats experimental model Myocardial infarction was induced by subcutaneous injection of ISO at the dose of and mg kg on two consecutive days th day and th day H MC at two doses and mg kg was administered orally for days before Iso administration Wistar rats were randomly assigned in experimental groups animals serve as a saline control saline plus ISO treated standard drug carvedilol mg kg p o plus ISO treatments test drug only treated groups received H MC and mg kg p o and test groups treated with the H MC low dose and higher dose with ISO The ISO treated rats show a significant elevation in cardiac toxicity markers enzymes lipid peroxidation modulate oxidative enzyme level infarct size and hemodynamic parameters The deformed by ISO was restored significantly by oral administration of H MC Test drug dose mg kg is more effective and it was also shown nearly similar results as that of standard drug Our study demonstrates that H MC possessing antioxidant activity and has a significant protective effect against ISO induced myocardial infarction We believe that pre treatment with H MC may contribute to developing novel strategies in the prevention and treatment of cardiotoxic effects of elevated level of catecholamines