Key result
Impaired coronary flow reserve (CFR ≤ 1.65) was associated with a higher rate of major adverse cardiovascular events compared to the highest CFR tertile (32.6% vs 15.5% per year, P=0.004).
Why the study?
Does impaired coronary flow reserve predict major adverse cardiovascular events in patients with ischaemic and non-ischaemic cardiomyopathy?
Population
510 consecutive patients with ischaemic and non-ischaemic cardiomyopathy, rest left ventricular ejection…
Comparison
Impaired coronary flow reserve assessed by… vs Preserved coronary flow reserve assessed by…
Design
Cohort
Follow-up
median 8.2 months
Authors
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Coronary flow reserve assessment may refine risk stratification in ICM/NICM; leaves open whether it guides therapy or improves outcomes.
Cohort (n=510)
Does impaired coronary flow reserve predict major adverse cardiovascular events in patients with ischaemic and non-ischaemic cardiomyopathy?
Absolute Event Rate: 32.6% vs 15.5%
p-value: p=0.004
Impaired coronary flow reserve assessed by PET imaging is associated with an increased risk of major adverse cardiovascular events in patients with cardiomyopathy, regardless of ischaemic or non-ischaemic aetiology.
Majmudar et al. (2015) conducted a cohort in Ischaemic and non-ischaemic cardiomyopathy (n=510). Impaired coronary flow reserve (CFR ≤ 1.65) vs. Highest tertile of CFR was evaluated on Composite of major adverse cardiovascular events (MACE) including cardiac death, heart failure hospitalization, late revascularization, and aborted sudden cardiac death (p=0.004). Impaired coronary flow reserve (CFR ≤ 1.65) was associated with a higher rate of major adverse cardiovascular events compared to the highest CFR tertile (32.6% vs 15.5% per year, P=0.004).
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