Why the study?
Understanding the prevalence of impaired CFR and identifying risk markers for it are needed to develop personalized treatments for high-risk patients with prior MI.
What is the prevalence of impaired coronary flow reserve and its predictors in high-risk patients with prior myocardial infarction?
Population
619 high-risk patients with a history of type-1 MI from SCAAR
Design
Prospective, exploratory, cross-sectional open study
Key result
In high-risk patients with prior myocardial infarction, 39.7% had impaired coronary flow reserve (≤2.5), which was independently predicted by traditional cardiovascular risk factors.
Authors
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High prevalence of impaired CFR post-MI; hypothesis-generating for CFR-based risk stratification, prospective validation needed.
Cross-Sectional (n=619)
Open-label
What is the prevalence of impaired coronary flow reserve and its predictors in high-risk patients with prior myocardial infarction?
A substantial proportion of high-risk patients with prior MI have impaired coronary flow reserve despite optimal medical therapy and lack of angina, suggesting a potential role for CFR in further risk stratification.
Haraldsson et al. (2019) conducted a cross-sectional in Prior type-1 myocardial infarction (n=619). Coronary flow reserve (CFR) was evaluated on Coronary flow reserve and its independent predictors. In high-risk patients with prior myocardial infarction, 39.7% had impaired coronary flow reserve (≤2.5), which was independently predicted by traditional cardiovascular risk factors.
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