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March 1, 2010Echocardiography

Coronary flow velocity reserve was an independent predictor of survival in patients with significant coronary artery disease not involving the LAD (HR 6.26; 95% CI 1.23-19.61; P=0.024).

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Why the study?

Does coronary flow velocity reserve predict cardiovascular mortality in patients with significant RC and/or CX stenosis without LAD disease?

Population

49 patients with significant right and/or left circumflex coronary artery stenosis without epicardial left…

Design

Cohort

Follow-up

mean 97 +/- 29 months

Key result

Coronary flow velocity reserve was an independent predictor of survival in patients with significant coronary artery disease not involving the LAD (HR 6.26; 95% CI 1.23-19.61; P=0.024).

Authors

ANAttila NemesUniversity of SzegedEBErika BalázsUniversity of SzegedSPSzilvia PintérCorvinus University of Budapest

Discussion

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Overview

May aid risk stratification in non-LAD CAD; leaves open whether CFVR should guide therapy, pending prospective validation.

Study Design

Type

Cohort (n=49)

Structured PICO

Does coronary flow velocity reserve predict cardiovascular mortality in patients with significant RC and/or CX stenosis without LAD disease?

P
Population
49 patients with significant right and/or circumflex coronary artery stenosis without LAD disease, followed for a mean of 97 months.
E
Exposure
Coronary flow velocity reserve (CFR) measurement by dipyridamole stress transoesophageal echocardiography
O
Outcome
Cardiovascular mortalityhard clinical

Main Result

Hazard Ratio: 6.26 (95% CI 1.23–19.61)

p-value: p=0.024

Coronary flow velocity reserve measured by transesophageal echocardiography is a strong independent predictor of long-term cardiovascular mortality in patients with non-LAD coronary artery disease.

Cite This Study

Nemes et al. (2010) conducted a cohort in Significant coronary artery disease not involving the LAD (n=49). Coronary flow velocity reserve (CFR) vs. Higher CFR was evaluated on Survival (HR 6.26, 95% CI 1.23-19.61, p=0.024). Coronary flow velocity reserve was an independent predictor of survival in patients with significant coronary artery disease not involving the LAD (HR 6.26; 95% CI 1.23-19.61; P=0.024).

synapsesocial.com/papers/6a881814afcf99b77fbbf8echttps://doi.org/10.1111/j.1540-8175.2009.01020.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The prognostic significance of coronary flow reserve in the risk stratification of patients with chronic total occlusion of the right coronary artery and the intermediary stenosis of the left coronary artery2020
  2. 2Long‐term prognostic role of coronary flow velocity reserve in patients with aortic valve stenosis – insights from the SZEGED Study2009 · 43 citations
  3. 3Diagnostic and prognostic value of Doppler echocardiographic coronary flow reserve in the left anterior descending artery2011 · 69 citations
  4. 4Prognostic value of Doppler echocardiographic-derived coronary flow velocity reserve of left anterior descending artery in octogenarians with stress echocardiography negative for wall motion criteria2015 · 24 citations
  5. 5Coronary flow velocity reserve reduction by Doppler echocardiography and independent association with mortality in patients with normal coronary arteries2025