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January 14, 2015European Heart Journal - Cardiovascular ImagingOpen Access

CFVR ≤ 1.93 was a strong independent predictor of mortality (HR = 2.17, 95% CI 1.14-4.10) and MACEs (HR = 2.69, 95% CI 1.56-4.67).

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Why the study?

Does a reduced CFVR (≤ 1.93) predict mortality and MACE in octogenarians with known or suspected CAD and stress echo negative for wall motion criteria?

Population

369 patients aged > 80 years with known or suspected coronary artery disease who had undergone dipyridamole…

Comparison

Doppler-derived coronary flow velocity reserve… vs CFVR > 1.93

Design

Cohort

Follow-up

median 21 months

Authors

LCLauro CortigianiFRF RigoSGSonia Gherardi

Discussion

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Overview

May refine risk stratification in octogenarians with negative stress echo; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does a reduced CFVR (≤ 1.93) predict mortality and MACE in octogenarians with known or suspected CAD and stress echo negative for wall motion criteria?

P
Population
369 patients aged > 80 years (156 men; mean age 83 ± 2 years) with known (n = 144) or suspected (n = 225) coronary artery disease who had undergone dipyridamole stress echocardiography negative for wall motion criteria.
I
Intervention
Doppler-derived coronary flow velocity reserve (CFVR) of left anterior descending (LAD) artery ≤ 1.93
C
Comparator
CFVR > 1.93
O
Outcome
Mortality and major adverse cardiac events (MACEs; deaths and non-fatal myocardial infarctions) at median 21 months follow-uphard clinical

In octogenarians with negative stress echocardiography by wall motion criteria, a reduced CFVR of the LAD artery (≤ 1.93) is a strong independent predictor of mortality and MACE.

Cite This Study

Cortigiani et al. (2015) studied this question.

synapsesocial.com/papers/6a894859a4df84145ecafdd7https://doi.org/10.1093/ehjci/jeu311
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long‐Term Prognostic Significance of Coronary Flow Velocity Reserve in Patients with Significant Coronary Artery Disease Not Involving the Left Anterior Descending Coronary Artery (Results from the SZEGED Study)2010 · 9 citations
  2. 2The additive prognostic value of coronary flow velocity reserve during exercise echocardiography2016 · 19 citations
  3. 3Coronary flow velocity reserve reduction by Doppler echocardiography and independent association with mortality in patients with normal coronary arteries2025
  4. 4Diagnostic and prognostic value of Doppler echocardiographic coronary flow reserve in the left anterior descending artery2011 · 69 citations
  5. 5P4984The functional and coronary anatomic correlates of coronary flow velocity reserve during stress echocardiography2019 · 10 citations