Key result
An abnormal coronary flow reserve (≤2.0) in patients with left bundle branch block was associated with a higher risk of death or MI compared to CFR >2.0 (HR 3.91; 95% CI 1.90-8.04; P<0.0001).
Why the study?
Does abnormal Doppler-derived coronary flow reserve (CFR ≤ 2.0) predict mortality and myocardial infarction in patients with left bundle branch block?
Population
324 patients with left bundle branch block and known or suspected coronary artery disease, mean age 68, 187…
Comparison
Abnormal coronary flow reserve assessed by… vs Normal coronary flow reserve (CFR > 2.0).
Design
Cohort
Follow-up
median 15 months (IQR 8-34 months)
Authors
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Abnormal CFR may aid risk stratification in LBBB; leaves open whether CFR-guided therapy improves outcomes.
Cohort (n=324)
Does abnormal Doppler-derived coronary flow reserve (CFR ≤ 2.0) predict mortality and myocardial infarction in patients with left bundle branch block?
Hazard Ratio: 3.91 (95% CI 1.9–8.04)
Absolute Event Rate: 56% vs 8%
p-value: p=<0.0001
In patients with LBBB, an abnormal coronary flow reserve (≤ 2.0) during dipyridamole stress echocardiography is a strong, independent predictor of mortality and myocardial infarction.
Cortigiani et al. (2012) conducted a cohort in Left bundle branch block with known or suspected coronary artery disease (n=324). Abnormal coronary flow reserve (CFR ≤ 2.0) vs. Normal coronary flow reserve (CFR > 2.0) was evaluated on Death or myocardial infarction (HR 3.91, 95% CI 1.90-8.04, p=<0.0001). An abnormal coronary flow reserve (≤2.0) in patients with left bundle branch block was associated with a higher risk of death or MI compared to CFR >2.0 (HR 3.91; 95% CI 1.90-8.04; P<0.0001).
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