Key result
Deferral of revascularization for medical treatment based on a coronary flow reserve > 2 resulted in similar survival from cardiac events compared to PTCA (86.4% vs 88.3%; P=0.36).
Why the study?
Does deferral of revascularization based on noninvasive CFR > 2 result in similar clinical outcomes compared to PTCA in patients with intermediate LAD stenosis?
Population
280 patients with intermediate left anterior descending coronary artery stenosis, mean age 62.2 +/- 9.6 years.
Comparison
Medical treatment guided by noninvasive… vs Percutaneous transluminal coronary angioplasty…
Design
Cohort
Follow-up
mean 43 +/- 11 months (range 12-52 months)
Authors
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May support deferral of PTCA for intermediate LAD stenosis with CFR >2; leaves open need for randomized confirmation.
Cohort (n=280)
Does deferral of revascularization based on noninvasive CFR > 2 result in similar clinical outcomes compared to PTCA in patients with intermediate LAD stenosis?
Absolute Event Rate: 86.4% vs 88.3%
p-value: p=0.36
Deferral of revascularization for intermediate LAD stenosis based on a noninvasive CFR > 2 yields similar long-term clinical outcomes compared to PTCA for CFR <= 2.
D’Andrea et al. (2008) conducted a cohort in Intermediate stenosis of the left anterior descending coronary artery (n=280). Medical treatment (CFR > 2) vs. PTCA (CFR <= 2) was evaluated on Cardiac death, myocardial infarction, coronary revascularization procedure, and unstable angina (p=0.36). Deferral of revascularization for medical treatment based on a coronary flow reserve > 2 resulted in similar survival from cardiac events compared to PTCA (86.4% vs 88.3%; P=0.36).
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