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Demonstrates efficient synthesis of isoquinolones using a nickel catalyst, suggesting new pathways for drug development.
1,2,3-Benzotriazin-4(3H)-ones reacted with internal and terminal alkynes in the presence of a nickel(0)/phosphine catalyst to give a wide range of substituted 1(2H)-isoquinolones in high yield. The reaction proceeded through denitrogenative activation of the triazinone moiety and the following insertion of alkynes.
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Miura et al. (2008) studied this question.
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