Synthesis of 1-(1H-Indol-3-yl)-1,2-dihydroisoquinolines via AgOTf-Catalyzed Three-Component Reactions of 2-Alkynylbenzaldehydes, Amines, and Indoles

This is the authors' abstract. We don't add key points for this paper.

Three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles catalyzed by AgOTf under mild conditions afford the 1-(1H-indol-3-yl)-1,2-dihydroisoquinolines in good yields. This silver-catalyzed tandem reaction is found to be workable with various indoles, anilines or alkyl amines, and 2-alkynylbenzaldehydes with electron-withdrawing groups attached on the aromatic backbone.