Key result
Pulmonary valve replacement in patients with corrected tetralogy of Fallot and preoperative QRS ≥180 ms resulted in an initial QRS shortening of 12.2 ms (p<0.001), followed by a steady widening.
Why the study?
Does pulmonary valve replacement improve QRS duration in adult patients with corrected tetralogy of Fallot?
Cohort (n=99)
Yes
Does pulmonary valve replacement improve QRS duration in adult patients with corrected tetralogy of Fallot?
Mean Difference: -12.2
p-value: p=<0.001
Pulmonary valve replacement provides only a transient reduction in QRS duration in patients with corrected tetralogy of Fallot and preoperative QRS >150 ms, with subsequent steady widening over time.
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Transient QRS narrowing after PVR in TOF cautions against expecting sustained benefit; leaves open effects on arrhythmia risk.
Oosterhof et al. (2006) conducted a cohort in corrected tetralogy of Fallot (n=99). pulmonary valve replacement vs. preoperative QRS duration was evaluated on change in QRS duration after surgery in patients with preoperative QRS ≥180 ms (mean decrease 12.2 ms, p=<0.001). Pulmonary valve replacement in patients with corrected tetralogy of Fallot and preoperative QRS ≥180 ms resulted in an initial QRS shortening of 12.2 ms (p<0.001), followed by a steady widening.
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