Key result
Human induced pluripotent stem cell-derived cardiovascular models hold promise as a faithful platform to predict cardiovascular toxicity of cancer therapies and understand underlying mechanisms.
Why the study?
Common chemotherapies cause acute and chronic cardiovascular complications, while preclinical human stem cell-derived cardiovascular models offer a platform to predict cardiotoxicity and understand underlying mechanisms.
Human induced pluripotent stem cell-derived cardiomyocytes offer a promising preclinical platform for predicting and understanding the cardiotoxic effects of cancer therapies.
iPSC models merit expanded cardio-oncology research use; leaves open clinical adoption pending prospective validation.
As common chemotherapeutic agents are associated with an increased risk of acute and chronic cardiovascular complications, a new clinical discipline, cardio-oncology, has recently emerged. At the same time, the development of preclinical human stem cell-derived cardiovascular models holds promise as a more faithful platform to predict the cardiovascular toxicity of common cancer therapies and advance our understanding of the underlying mechanisms contributing to the cardiotoxicity. In this article, we review the recent advances in preclinical cancer-related cardiotoxicity testing, focusing on new technologies, such as human induced pluripotent stem cell-derived cardiomyocytes and tissue engineering. We further discuss some of the limitations of these technologies and present future directions. Stem Cells Translational Medicine 2019;8:758&767.
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Nair et al. (2019) conducted a review in Cancer-related cardiotoxicity. Human induced pluripotent stem cell-derived cardiovascular models was evaluated. Human induced pluripotent stem cell-derived cardiovascular models hold promise as a faithful platform to predict cardiovascular toxicity of cancer therapies and understand underlying mechanisms.
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