Key result
The ATOPE trial is a randomized protocol designed to evaluate whether a tailored therapeutic exercise program performed before treatment mitigates cardiotoxicity in 120 women with breast cancer.
Why the study?
It is unknown whether delivering a tailored therapeutic exercise program before anticancer treatment mitigates cardiotoxicity more effectively than delivering it during treatment in women recently diagnosed with breast cancer.
Does the ATOPE program performed before treatment mitigate cardiotoxicity compared to when performed during treatment in women recently diagnosed with breast cancer?
Population
120 women recently diagnosed with breast cancer awaiting surgery followed by chemotherapy and/or radiotherapy
Comparison
ATOPE program performed before treatment vs during treatment
Design
Randomized controlled trial protocol
Follow-up
3 years after treatment ends
Authors
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This trial protocol outlines a study to determine if a tailored high-intensity exercise program performed before breast cancer treatment can better mitigate cardiotoxicity compared to exercise during treatment.
RCT (n=120)
randomized
Does the ATOPE program performed before treatment mitigate cardiotoxicity compared to when performed during treatment in women recently diagnosed with breast cancer?
This trial protocol outlines a study to determine if a tailored high-intensity exercise program performed before breast cancer treatment can better mitigate cardiotoxicity compared to exercise during treatment.
Postigo-Martín et al. (2021) conducted an RCT in Breast cancer (n=120). Tailored Therapeutic Exercise and Recovery Strategies (ATOPE) program before treatment vs. ATOPE program followed during treatment was evaluated on Cardiotoxicity, assessed echocardiographically via the left ventricular ejection fraction. The ATOPE trial is a randomized protocol designed to evaluate whether a tailored therapeutic exercise program performed before treatment mitigates cardiotoxicity in 120 women with breast cancer.