Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 27, 2026iScienceOpen Access

AI-augmented MALDI-TOF MS screening reveals a high burden of undiagnosed monoclonal gammopathy in adult patients

View Full Paper
Ask AI
Bookmark
Share

Authors

JHJunda HuangLinköping UniversityZLZewen LiZhujiang HospitalECEnzhong ChenZhujiang Hospital

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates high rates of undiagnosed monoclonal gammopathy in adults, indicating a need for enhanced screening methods.

Key Points

  • The aim is to identify the prevalence of undiagnosed monoclonal gammopathy using AI-augmented MALDI-TOF MS screening.
  • Developed an AI-augmented MALDI-TOF MS platform for M-protein detection.
  • Trained and validated the platform on 5,218 retrospective serum samples.
  • Deployed the system in a real-world cohort of 12,263 adult patients.
  • M-proteins identified in 7.5% of patients and 10.1% in those aged ≥ 50 years.
  • Detected a substantial burden of previously undetected monoclonal protein abnormalities.
  • M-protein positivity correlated with diverse infections, neoplasms, and metabolic disorders.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a67004840bca442e0d4a04dhttps://doi.org/10.1016/j.isci.2026.116923
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study2009 · 1,145 citations
  2. 2Endogenous monoclonal immunoglobulins analyzed using the EXENT® solution and LC-MS2024 · 21 citations
  3. 3ICD-11: an international classification of diseases for the twenty-first century2021 · 581 citations
  4. 4Diagnosis and Management of Monoclonal Gammopathy of Undetermined Significance2025 · 36 citations
  5. 5Disease associations with monoclonal gammopathy of undetermined significance can only be evaluated using screened cohorts: results from the population-based iStopMM study2023 · 48 citations