What does this research mean for the field?

The circular RNA circCDR1as promotes pathological cardiac hypertrophy and heart failure by binding to SERCA2a and enhancing its NEDD4L-mediated ubiquitination and degradation, thereby disrupting calcium homeostasis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to investigate the role of circCDR1as in cardiac hypertrophy and its associated molecular mechanisms.

July 27, 2026Journal of Translational MedicineOpen Access

The functional role of the circular RNA circCDR1as targeting SERCA2a in the progression of pathological cardiac hypertrophy and heart failure

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Authors

YWYi-Xiang Wang WLWenjie Liao HLHongda Li

Discussion

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Overview

Randomized trial explores the role of circCDR1as in cardiac hypertrophy, indicating its potential as a therapeutic target.

Key Points

The study aims to investigate the role of circCDR1as in cardiac hypertrophy and its associated molecular mechanisms.
Utilized a mouse model of pressure overload-induced hypertrophy via transverse aortic constriction (TAC).
Identified SERCA2a as an interacting protein of circCDR1as using mass spectrometry after RNA pull-down.
Examined the effects of circCDR1as manipulation on cardiac function and hypertrophy in mice.
CircCDR1as was found to be upregulated in the blood of patients with cardiac hypertrophy, suggesting a potential independent risk factor.
Knockdown of circCDR1as improved cardiac function and reduced hypertrophy post-TAC surgery.
Overexpression of circCDR1as using AAV9 resulted in increased hypertrophic response and heart failure development.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a67004840bca442e0d4a06d https://doi.org/10.1186/s12967-026-08670-5

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July 27, 2026Journal of Translational MedicineOpen Access

The functional role of the circular RNA circCDR1as targeting SERCA2a in the progression of pathological cardiac hypertrophy and heart failure

View Full Paper

Ask AI

Bookmark

Authors

YWYi-Xiang Wang WLWenjie Liao HLHongda Li

Discussion

Member takes

Overview

Randomized trial explores the role of circCDR1as in cardiac hypertrophy, indicating its potential as a therapeutic target.

Key Points

The study aims to investigate the role of circCDR1as in cardiac hypertrophy and its associated molecular mechanisms.
Utilized a mouse model of pressure overload-induced hypertrophy via transverse aortic constriction (TAC).
Identified SERCA2a as an interacting protein of circCDR1as using mass spectrometry after RNA pull-down.
Examined the effects of circCDR1as manipulation on cardiac function and hypertrophy in mice.
CircCDR1as was found to be upregulated in the blood of patients with cardiac hypertrophy, suggesting a potential independent risk factor.
Knockdown of circCDR1as improved cardiac function and reduced hypertrophy post-TAC surgery.
Overexpression of circCDR1as using AAV9 resulted in increased hypertrophic response and heart failure development.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a67004840bca442e0d4a06d https://doi.org/10.1186/s12967-026-08670-5

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