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July 27, 2026Blood Cancer JournalOpen Access

Selinexor for myelofibrosis or a drug in search of a disease?

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Authors

NGNaseema GangatATAyalew Tefferi

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Overview

Randomized trial explores the effects of selinexor in treating myelofibrosis, suggesting new therapeutic options.

Key Points

  • The aim is to evaluate the therapeutic potential of selinexor in patients with myelofibrosis.
  • Investigated the role of XPO1 inhibition in JAK2V617F-mutant cells.
  • Utilized preclinical murine models to assess efficacy.
  • Assessed the selective suppression of clonal cells while preserving normal progenitors.
  • Selinexor demonstrated significant antitumor activity in JAK2V617F-mutant cells.
  • Induction of apoptosis was observed in malignant cells through XPO1 inhibition.
  • Therapeutic effects were identified in preclinical models, supporting its use in myelofibrosis.

Cite This Study

Gangat et al. (2026) studied this question.

synapsesocial.com/papers/6a67008840bca442e0d4a436https://doi.org/10.1038/s41408-026-01587-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1XPO1 inhibition by selinexor blocks nucleo-cytoplasmic trafficking of multiple members of the NF-kb family in MPN cell lines and primary myelofibrosis cells2025 · 1 citations
  2. 2Selinexor potentiates NK cell activation against multiple myeloma2026
  3. 3Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription ( <scp>JAK</scp> / <scp>STAT)</scp> signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment‐related pathways2026
  4. 4Single‐Agent Selinexor Versus Physician's Choice in Previously Treated Myelofibrosis: Results From the Phase 2 XPORT‐035 Study2026
  5. 5Refining the role of selinexor in multiple myeloma: strategic use in a shifting treatment landscape2026 · 1 citations