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July 27, 2026Clinical and Experimental MedicineOpen Access

Integrated transcriptomic analysis identifies an AKT1-associated metabolic-inflammatory signature in osteoporosis

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Authors

CBChenglong BaoRHRonggui Hu

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Overview

Randomized trial shows an AKT1-related metabolic-inflammatory signature in low-bone density, highlighting potential biomarkers for osteoporosis.

Key Points

  • The study aims to investigate the relationship between fatty acid metabolism and immune-inflammatory changes in low bone mineral density (Low-BMD).
  • Integrated three GEO datasets comprising 60 High-BMD controls and 59 Low-BMD subjects.
  • Performed differential expression analysis, immune infiltration analysis, and machine learning.
  • Evaluated the role of AKT1 through knockdown in cell models to measure inflammatory mediators.
  • Eighteen fatty acid metabolism-related genes were identified as differentially expressed between High-BMD and Low-BMD samples.
  • NMF clustering revealed two Low-BMD subtypes with unique metabolic and immune-inflammatory profiles.
  • AKT1 knockdown resulted in reduced secretion of IL-6, TNF-α, and IL-1β, confirming its role in regulating inflammatory responses.

Cite This Study

Bao et al. (2026) studied this question.

synapsesocial.com/papers/6a67008840bca442e0d4a48dhttps://doi.org/10.1007/s10238-026-02263-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A microbiota–substrate–metabolite–target network suggests AKT1-associated links between gut microbiota-derived metabolites and osteoporosis2026
  2. 2Activation of AKT1 enhances the capacity of senescent BMSCs to regulate osteoclast activation2025
  3. 3Development and experimental validation of an energy metabolism-related gene signature for diagnosing of osteoporosis2024 · 1 citations
  4. 4Analysis and validation of biomarkers of immune cell-related genes in postmenopausal osteoporosis: An observational study2024 · 1 citations
  5. 5Genome-Resolved Functional Profiling of Osteoporosis-Associated Gut Bacteria Highlights Putative Metabolic and Immunogenic Signatures of the Gut–Bone Axis2026