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July 27, 2026BMC PsychiatryOpen Access

A novel perspective on biomarkers of neurodegeneration and neuroinflammation in first episode psychosis: a cross-sectional study

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Authors

VZValeria ZakurazhnayaYZYana ZorkinaOAOlga Abramova

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Overview

Cross-sectional study identifies unique biomarker profiles in first episode psychosis, suggesting distinct biological signatures.

Key Points

  • This study aims to identify biomarkers differentiating first-episode psychosis from chronic schizophrenia and healthy controls.
  • Cross-sectional study design measuring serum concentrations of 18 biomarkers in 49 FEP patients, 80 SCH patients, and 80 healthy controls.
  • Biomarkers were analyzed using multiplex immunoassay and principal component analysis to identify patterns of biomarkers.
  • Correlation analysis determined relationships among biomarkers in each diagnostic group.
  • FEP showed significantly lower levels of YKL-40 and BDNF, elevated NCAM-1, decreased TDP-43, and higher Aβ1‑42 compared to SCH and CON groups.
  • SCH did not differ from CON on most biomarkers, indicating little distinction in chronic phase.
  • A unique biomarker network characterized by strong correlations was found in SCH, while FEP exhibited a distinct correlation between TDP-43 and YKL-40.

Cite This Study

Zakurazhnaya et al. (2026) studied this question.

synapsesocial.com/papers/6a6700af40bca442e0d4a96chttps://doi.org/10.1186/s12888-026-08381-7
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