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July 27, 2026Ecotoxicology and Environmental SafetyOpen Access

Acute low-salinity stress induces gill injury, oxidative stress, and apoptosis via the JNK-JUN/MAPK axis in the swimming crab (Portunus trituberculatus)

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Authors

XLXiang LuXAXin-Yao AnXLXin Liu

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Overview

Randomized trial reveals oxidative stress and apoptosis mechanisms in swimming crab gills, suggesting environmental impacts.

Key Points

  • This research aims to explore the molecular mechanisms behind gill injury and oxidative stress in Portunus trituberculatus due to low-salinity exposure.
  • Integrated histopathology, biochemical assays, transcriptomics, RNA interference, and western blotting.
  • Assessed antioxidant enzyme activities and cell apoptosis in gills under low-salinity stress.
  • Investigated the activation of the JNK-JUN/MAPK axis.
  • Antioxidant enzymes (SOD, CAT) activities increased initially but decreased later in gills.
  • Significant epithelial cell detachment and apoptosis were evident in the posterior gills.
  • JNK inhibition worsened epithelial detachment and apoptosis, confirming the JNK-JUN/MAPK axis role in stress adaptation.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a6700af40bca442e0d4a98dhttps://doi.org/10.1016/j.ecoenv.2026.120543
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