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July 27, 2026Scientific ReportsOpen Access

The role of serum biochemical markers in early prediction of complicated appendicitis: a single-center retrospective analysis

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Authors

KLKai LuKLKe LanLZLongquan Zou

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Overview

Retrospective analysis identifies serum biomarkers predicting complicated appendicitis, suggesting improved early diagnosis.

Key Points

  • Identify serum biochemical markers associated with complicated appendicitis to establish a predictive model.
  • Retrospective analysis of biochemical profiles in patients with uncomplicated and complicated appendicitis.
  • Analysis performed using SPSS for statistical significance and R for diagnostic performance.
  • Multivariate logistic regression to identify independent risk factors among 265 patients.
  • C-reactive protein (OR = 6.725, P < 0.001) and neutrophil-to-lymphocyte ratio (OR = 2.238, P < 0.001) identified as independent risk factors.
  • Predictive model combining CRP, NLR, ALB, and age achieved an AUC of 0.899, with 90% sensitivity and 77% specificity.
  • CRP levels above 51.55 mg/L indicate a high likelihood of complicated appendicitis.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a6700af40bca442e0d4aa39https://doi.org/10.1038/s41598-026-62236-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood biomarkers to distinguish complicated and uncomplicated appendicitis in pediatric patients2024 · 19 citations
  2. 2C-Reactive protein and the CALLY index for predicting complicated appendicitis: a retrospective cohort study of 5,428 patients2026
  3. 3Diagnostic accuracy of the c-reactive protein to albumin ratio for identifying complicated appendicitis in adults: a retrospective study2026
  4. 4International normalized ratio and serum C-reactive protein are feasible markers to predict complicated appendicitis2016 · 23 citations
  5. 5Evaluating Lactate and CRP for Preoperative Risk Stratification in Acute Appendicitis: A Retrospective Study2026