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March 26, 2026Konuralp Tıp DergisiOpen Access

Evaluating Lactate and CRP for Preoperative Risk Stratification in Acute Appendicitis: A Retrospective Study

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Authors

MÇMehmet Fuat ÇetinFGFatih GürsoyMGMehmet Emin GÖNÜLLÜ

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Overview

This retrospective study evaluates lactate and CRP levels for assessing appendicitis severity, suggesting possible clinical applications.

Key Points

  • The aim is to assess the effectiveness of lactate and CRP in distinguishing between complicated and uncomplicated appendicitis.
  • Retrospective analysis of 156 patients who underwent appendectomy from 2018 to 2024.
  • Patients classified as complicated or uncomplicated based on operative and histopathological findings.
  • Preoperative serum lactate and CRP levels analyzed using ROC curves and multivariate logistic regression.
  • Complicated appendicitis was associated with significantly higher median lactate (2.5 vs 1.6 mmol/L) and CRP levels (85 vs 32 mg/L).
  • Lactate had a fair to good discriminative ability (AUC 0.82), while CRP showed moderate performance (AUC 0.78).
  • Lactate, CRP, and body temperature identified as independent predictors in multivariate analysis, albeit with modest effect sizes.

Cite This Study

Çetin et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc85fdc3bde448917d0dhttps://doi.org/10.18521/ktd.1785244
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association of early postoperative lactate levels with morbidity after elective major abdominal surgery2018 · 53 citations
  2. 2Systemic inflammatory indices and age-dependent severity in acute appendicitis: a retrospective cohort study2025 · 8 citations
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  4. 4The global, regional, and national burden of appendicitis in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 20192023 · 129 citations
  5. 5Normal inflammatory markers in appendicitis: evidence from two independent cohort studies2011 · 36 citations