Key result
High serum CRP levels (≥50 mg/L) significantly predicted complicated appendicitis prior to surgery, yielding a positive predictive value of 52.7% that increased to 82.6% at levels ≥150 mg/L.
Why the study?
Preoperative distinction between uncomplicated and complicated appendicitis guides treatment decisions, and combining clinical and imaging factors could improve diagnostic reliability.
Do preoperative clinical factors and scoring models predict complicated appendicitis in patients with acute appendicitis?
Population
203 patients preoperatively diagnosed with acute appendicitis
Comparison
151 uncomplicated appendicitis vs 52 complicated appendicitis patients
Design
Single-center observational study
Authors
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Elevated CRP may aid preoperative appendicitis risk stratification; hypothesis-generating and requires prospective validation before changing practice.
Observational (n=203)
No
Do preoperative clinical factors and scoring models predict complicated appendicitis in patients with acute appendicitis?
Absolute Event Rate: 76.5% vs 23.2%
p-value: p=<0.001
High serum CRP levels, along with specific CT findings and clinical scoring models, are useful for preoperatively predicting complicated appendicitis.
Fujiwara et al. (2021) conducted an observational in Acute appendicitis (n=203). High serum CRP level (≥50 mg/L) vs. Serum CRP level <50 mg/L was evaluated on Presence of complicated appendicitis (p=<0.001). High serum CRP levels (≥50 mg/L) significantly predicted complicated appendicitis prior to surgery, yielding a positive predictive value of 52.7% that increased to 82.6% at levels ≥150 mg/L.
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