Effects of bangle (Zingiber purpureum) rhizome extract on physical function and oral microbiota in community-dwelling older adults: A double-blind, placebo-controlled trial

Functional foods containing bioactive compounds are increasingly studied as non-pharmacological strategies to support physical function and healthy aging in older adults. Bangle ( Zingiber purpureum ) rhizome extract (BRE) contains phenylbutenoid dimers (banglenes) with exercise-mimetic properties and neurotrophic-related activities reported, as well as inhibitory activity against oral periodontopathogens; however, controlled human evidence is limited. This randomized, double-blind, placebo-controlled trial assessed BRE effects on physical function, nutritional intake, and the oral environment in community-dwelling older adults. Ninety participants received BRE (150 mg/day, 300 mg/day), or placebo for 6 months. Compared with placebo, both BRE doses significantly improved walking speed and Timed Up and Go (TUG) performance (primary outcomes). In addition, BRE intake was associated with higher energy intake, improved salt taste sensitivity, and lower oral P. gingivalis expression (secondary/exploratory outcomes). These findings suggest that BRE intake may provide clinically meaningful improvements.