What question did this study set out to answer?

To evaluate the anti-oxidant and anti-ulcer effects of a polyherbal formulation in NSAID-induced gastric ulcer models.

July 27, 2026Open Access

Evaluation of Anti-Oxidant and Anti-Ulcer Activity of a Polyherbal Formulation in Nsaids-Induced Ulcer Model

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Authors

MAMandapati Apoorva*American Association of Colleges of Pharmacy SNSaikrishna NallajerlaAmerican Association of Colleges of Pharmacy

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Implication

Randomized trial evaluates antioxidant and gastroprotective effects of a polyherbal formulation in Wistar rats, suggesting a potential natural remedy for NSAID-induced gastric ulcers.

Key Points

To evaluate the anti-oxidant and anti-ulcer effects of a polyherbal formulation in NSAID-induced gastric ulcer models.
Formulated a polyherbal preparation from selected medicinal plants.
Assessed antioxidant activity using DPPH assay and evaluated anti-ulcer activity in aspirin-induced gastric ulcer models in Wistar rats.
Conducted acute oral toxicity evaluation per OECD Guideline 423.
The formulation significantly decreased the ulcer index and increased gastric pH, with dose-dependent gastroprotective effects comparable to omeprazole.
Demonstrated concentration-dependent DPPH radical scavenging activity, indicating strong antioxidant potential.
No mortality or toxic effects were observed at 2000 mg/kg in acute toxicity studies.

Cite This Study

Apoorva* et al. (2026) studied this question.

synapsesocial.com/papers/6a6700c740bca442e0d4ad76 https://doi.org/10.5281/zenodo.21542835

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Implication

Randomized trial evaluates antioxidant and gastroprotective effects of a polyherbal formulation in Wistar rats, suggesting a potential natural remedy for NSAID-induced gastric ulcers.

Evaluation of Anti-Oxidant and Anti-Ulcer Activity of a Polyherbal Formulation in Nsaids-Induced Ulcer Model

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluation of Anti-Oxidant and Anti-Ulcer Activity of a Polyherbal Formulation in Nsaids-Induced Ulcer Model

Discussion

Member takes

Implication

Key Points

Cite This Study

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