Randomized trial evaluates antioxidant and anti-ulcer effects of a polyherbal formulation in Wistar rats, suggesting a natural alternative for NSAID-induced gastric ulcers.
Key Points
This research aims to evaluate the antioxidant and anti-ulcer effects of a polyherbal formulation in an NSAIDs-induced ulcer model.
Prepared a polyherbal formulation from selected medicinal plants.
Conducted antioxidant activity tests using the DPPH assay and assessed anti-ulcer effects in aspirin-induced gastric ulcer models using Wistar rats.
Performed acute oral toxicity evaluations according to OECD Guideline 423.
Phytochemical screening confirmed flavonoids, tannins, phenolic compounds, glycosides, and saponins in the formulation.
The formulation showed concentration-dependent DPPH radical scavenging activity, indicating significant antioxidant potential; acute toxicity studies showed no toxicity at 2000 mg/kg.
In the aspirin-induced ulcer model, the formulation significantly reduced the ulcer index and increased gastric pH compared to controls, demonstrating gastroprotective activity.