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This review aims to assess the utility of BH3 profiling in predicting cancer treatment responses and its application in precision oncology.

July 27, 2026OncogenesisOpen Access

BH3 profiling analyses for functional precision medicine

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Review evaluates BH3 profiling's ability to predict treatment response in cancer, suggesting better personalized therapies.

This review aims to assess the utility of BH3 profiling in predicting cancer treatment responses and its application in precision oncology.
Evaluated preclinical and clinical studies involving BH3 profiling across various cancer types.
Discussed advancements in high-throughput and dynamic BH3 profiling techniques.
Analyzed the correlation between BH3 profiling results and treatment outcomes, particularly in hematologic malignancies and solid tumors.
BH3 profiling effectively predicts treatment responses, notably showing that functional dependence on BCL-2 correlates with sensitivity to venetoclax.
Analysis reveals that solid tumors exhibit reliance on BCL-xL and MCL-1, aiding in combination strategy designs.
Methodological advancements highlight the variability in apoptotic regulation within tumors, suggesting enhancements for clinical application.

Morales-Sánchez et al. (2026) studied this question.

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