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This research investigates how endothelial cell proliferation varies with age in different tissues.

July 27, 2026npj Cardiovascular HealthOpen Access

Proliferation dynamics of organotypic vascular endothelium during aging

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Randomized trial evaluates endothelial cell proliferation in aging mouse models, suggesting organ-specific changes in capacity.

This research investigates how endothelial cell proliferation varies with age in different tissues.
Cumulative labeling of proliferating endothelial cells was employed.
A temporal map of EC changes across three life stages (juvenile, young adult, old adult) in mice was created.
Comparative analyses examined 12 organs for age-related patterns of endothelial proliferation.
Lung endothelial cells exhibited increased proliferation during aging.
Adipose, colon, and liver tissues showed reduced endothelial proliferation.
Most vascular beds retained some proliferative capacity, indicating organ-specific dynamics.

Mao et al. (2026) studied this question.

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