Key result
A continuum mathematical model predicts that the age of the endothelium corresponds to a Gaussian-like distribution of cell generations, and enhanced stem cell homing can halt or reverse this aging process.
Population
Continuum mathematical model of large endothelial cell populations of the endothelium
Design
Other
Authors
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Suggests stem cell homing as potential target to slow endothelial aging; hypothesis-generating and requires validation before clinical consideration.
A mathematical model suggests that the aging of the endothelium is driven by cellular senescence and depends sensitively on the homing rates of endothelial progenitor cells.
Wang et al. (2007) studied Endothelial aging and senescence. Stem cell homing (mathematical simulation) was evaluated on Cell generation profile and healing time of damaged endothelium. A continuum mathematical model predicts that the age of the endothelium corresponds to a Gaussian-like distribution of cell generations, and enhanced stem cell homing can halt or reverse this aging process.
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