Key result
In individuals with non-alcoholic fatty liver disease, renal sinus fat was significantly associated with higher urinary albumin-to-creatinine ratio (beta = 0.40, p=0.0005).
Why the study?
Does fetuin-A alter the protective effect of renal sinus fat on glomerular cells and correlate with impaired renal function in patients with NAFLD?
Population
In vitro: human renal sinus fat cells cocultured with human endothelial cells or podocytes. In vivo: 449…
Comparison
Fetuin-A exposure; Presence of non-alcoholic… vs Absence of fetuin-A; Subjects without NAFLD
Design
Cross-sectional
Authors
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May link fetuin-A to RSF-driven renal impairment in NAFLD; hypothesis-generating and requires clinical validation before practice change.
Cross-Sectional (n=449)
No
Does fetuin-A alter the protective effect of renal sinus fat on glomerular cells and correlate with impaired renal function in patients with NAFLD?
Effect estimate: beta = 0.40
p-value: p=0.0005
In individuals with NAFLD, elevated fetuin-A levels may impair renal function by inducing proinflammatory signaling in renal sinus fat.
Wágner et al. (2017) conducted a cross-sectional in Risk for type 2 diabetes (n=449). Renal sinus fat (RSF) in the presence of NAFLD vs. Subjects without NAFLD was evaluated on Correlation between renal sinus fat (RSF) and urinary albumin/creatinine-ratio (uACR) (beta = 0.40, p=0.0005). In individuals with non-alcoholic fatty liver disease, renal sinus fat was significantly associated with higher urinary albumin-to-creatinine ratio (beta = 0.40, p=0.0005).
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