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November 1, 2016EBioMedicineOpen Access

Role of Renal Sinus Adipose Tissue in Obesity-induced Renal Injury

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Key result

Renal sinus adipose tissue accumulation directly correlated with early renal injury markers sKIM-1 and FGF-21 in 280 asymptomatic middle-age participants.

Population

280 asymptomatic middle-age participants, with a subset of 40 subjects prospectively followed over a 1-year…

Design

Editorial

Follow-up

1 year (for a subset of 40 subjects)

Authors

MIMaría V. IrazabalMayo ClinicAEAlfonso EirinVascular / Pulmonary Vascular

Discussion

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Overview

Hypothesis-generating for obesity-cardiovascular links; prospective studies needed before clinical inferences.

Structured PICO

P
Population
280 asymptomatic middle-age participants evaluated for renal sinus and abdominal adipose tissue volumes, with 40 subjects followed prospectively for 1 year.
O
Outcome
Correlation of renal sinus adipose tissue with early diagnostic biomarkers of kidney injury (serum kidney injury molecule-1 [sKIM-1] and fibroblast growth factor-21 [FGF-21])surrogate

Accumulation of adipose tissue in the renal sinus correlates with early biomarkers of kidney injury, highlighting a potential mechanism for obesity-induced renal damage.

Limitations

  • Further studies are needed to establish a cause-effect relationship between RS adipose tissue and renal dysfunction.
  • Need for further studies to establish a cause-effect relationship between RS adipose tissue and renal dysfunction

Cite This Study

Irazabal et al. (2016) conducted an editorial in Obesity-induced renal injury (n=280). Renal sinus adipose tissue accumulation was evaluated on Serum levels of kidney injury molecule (sKIM)-1 and fibroblast growth factor (FGF)-21. Renal sinus adipose tissue accumulation directly correlated with early renal injury markers sKIM-1 and FGF-21 in 280 asymptomatic middle-age participants.

synapsesocial.com/papers/6a676d3b4340feaedbb2a7ddhttps://doi.org/10.1016/j.ebiom.2016.11.002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase2016 · 42 citations
  2. 2Renal Sinus Fat and Poor Blood Pressure Control in Middle-Aged and Elderly Individuals at Risk for Cardiovascular Events2010 · 182 citations
  3. 3Fatty Kidney, Hypertension, and Chronic Kidney Disease2011 · 356 citations
  4. 4Ectopic Fat Storage, Insulin Resistance, and Hypertension2011 · 31 citations
  5. 5Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives2012 · 300 citations