Key result
Functional renal MR imaging using BOLD and chemical shift-selective techniques demonstrated higher fat and lower oxygen levels in the kidneys of diabetic mice compared to normal controls.
Why the study?
Does functional renal MR imaging detect differences in renal fat deposition and hypoxia in a mouse model of diabetes compared to normal controls?
Does functional renal MR imaging detect differences in renal fat deposition and hypoxia in a mouse model of diabetes compared to normal controls?
Functional renal MR imaging methods such as BOLD and chemical shift-selective imaging may help evaluate CKD severity by detecting hypoxia and fat deposition.
Despite being a valuable tool for evaluation of the kidneys, renal magnetic resonance (MR) imaging in clinical practice has been limited to depiction of anatomy and provides little diagnostic information about the health and function of the kidney in patients with chronic kidney disease (CKD) and diabetic nephropathy. In this issue, Peng et al (1) have used two MR imaging methods that go beyond depiction of anatomy to show renal function: renal blood oxygen level-dependent (BOLD) MR imaging, which shows oxygen levels in the kidney, and chemical shift-selective imaging, which shows the relative content of fat in the kidney parenchyma. In a mouse model of diabetes, Peng et al have shown higher fat and lower oxygen levels in kidneys of mice with diabetes than in those of normal controls. These MR imaging methods may help clarify the role of fat deposition and hypoxia in the progression of CKD. As the factors that contribute to the progression of CKD are better understood, ultimately more widespread clinical use for functional renal MR imaging protocols such as renal BOLD and chemical shift-selective imaging may be found to evaluate the severity of CKD and monitor the efficacy of clinical interventions, altering the course of disease progression.
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Morrell et al. (2013) conducted an editorial in Diabetic nephropathy. Renal BOLD MR imaging and chemical shift-selective imaging vs. Normal controls was evaluated on Renal cortical fat and T2* (oxygenation levels). Functional renal MR imaging using BOLD and chemical shift-selective techniques demonstrated higher fat and lower oxygen levels in the kidneys of diabetic mice compared to normal controls.
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