What does this research mean for the field?

Overexpression of thymidine phosphorylase (TYMP) and gelsolin (GSN), along with broader deregulation of cytoskeletal remodeling and nucleotide metabolism, are prominent features of intrinsic chemoresistance to vincristine and methotrexate in pediatric B-cell acute lymphoblastic leukemia. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to identify protein profiles associated with resistance to methotrexate and vincristine in B-ALL patients.

July 28, 2026PharmaceuticalsOpen Access

Proteomic Profiling of Bone Marrow Aspirates from Patients with Methotrexate- and Vincristine-Resistant B-Cell Acute Lymphoblastic Leukemia: A Retrospective Analysis

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This study aims to identify protein profiles associated with resistance to methotrexate and vincristine in B-ALL patients.
Conducted a retrospective analysis of bone marrow aspirates from responders and nonresponders to induction chemotherapy.
Utilized LC–MS/MS proteomics and bioinformatic analysis to evaluate protein expression.
Focused on proteins related to resistance mechanisms in treatment-naive patients.
Nonresponders exhibited a distinct proteomic profile with deregulation in cytoskeletal structure and nucleotide metabolism.
Thymidine phosphorylase and gelsolin were consistently overexpressed in nonresponders, indicating their potential as biomarkers.
Cytoskeletal remodeling and nucleotide metabolism were key features of intrinsic chemoresistance.

Authors

EFEsli Janai Flores-PalmaUniversidad Autónoma de Guerrero DGDiana Laura Gonzalez-TolentinoUniversidad Autónoma de Guerrero SESergio Encarnación‐GuevaraUniversidad Autónoma del Estado de Morelos

Discussion

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Implication

Retrospective analysis identifies protein markers linked to treatment resistance in pediatric B-ALL, suggesting future studies.

Cite This Study

Flores-Palma et al. (2026) studied this question.

synapsesocial.com/papers/6a6850fb2845b684d16f021b https://doi.org/10.3390/ph19081167

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Proteomic Profiling of Bone Marrow Aspirates from Patients with Methotrexate- and Vincristine-Resistant B-Cell Acute Lymphoblastic Leukemia: A Retrospective Analysis

Key Points

Discussion

Implication

Cite This Study

Proteomic Profiling of Bone Marrow Aspirates from Patients with Methotrexate- and Vincristine-Resistant B-Cell Acute Lymphoblastic Leukemia: A Retrospective Analysis

Key Points

Discussion

Implication

Cite This Study