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July 28, 2026Health Science ReportsOpen Access

Revealing Sex Disparities in the Burden of Diarrheal Diseases Among Children Under 5: Global and Asian Trends and Projections, 1990–2050 – A Population‐Based Observational Analysis Using GBD 2021 Data

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Population-based analysis reveals sex-specific trends in diarrheal diseases among children, highlighting regional disparities in Asia.

This study aims to investigate sex-specific disparities in the burden of diarrheal diseases among children under 5 years, focusing on long-term trends and future projections.
Analyzed sex-disaggregated data from the Global Burden of Disease 2021 Study.
Utilized hierarchical linear mixed-effects models for Asian countries and autoregressive integrated moving average models for forecasting.
Evaluated annual percentage changes to assess temporal trends in incidence, prevalence, mortality, and DALYs.
Between 1990 and 2021, males experienced consistently higher DALYs and mortality rates compared to females.
Significant regional disparities were observed, with the largest declines in Southeast Asia and South Asia, while High-income Asia Pacific saw limited progress.
Projections to 2050 indicate ongoing declines, but South and Southeast Asia will have the highest burden, with stagnant progress in Central Asia.

Amini et al. (2026) studied this question.

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