Global and Regional Myocardial Function Quantification by Two-Dimensional Strain
Key result
Two-dimensional strain echocardiography identified significantly reduced average longitudinal strain in patients with hypertrophic cardiomyopathy compared to healthy controls (-15.1% vs -20.3%, p<0.001).
Why the study?
Conventional Doppler-derived strain has been limited by poor reproducibility and angle dependency, prompting the use of a novel two-dimensional strain method to characterize systolic function abnormalities in HCM.
Population
26 patients with nonobstructive HCM and 45 healthy subjects
Comparison
Patients with nonobstructive HCM vs healthy subjects
Design
Case-control study
Authors
Discussion
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Implication
Randomized trial quantifies myocardial function in various regions, highlighting key insights on cardiac health.
Key Points
- This research aims to quantify global and regional myocardial function using two-dimensional strain imaging techniques.
- Utilized two-dimensional strain imaging to assess myocardial function.
- Analyzed data from various regions of the heart.
- Conducted a comparison between global and regional function metrics.
- Demonstrated significant differences in regional myocardial function across different heart areas.
- Quantified global myocardial function metrics, revealing important trends.
- Identified correlations between strain values and cardiac performance.
Study Design
Type
Case-Control (n=71)
PICO
P
Population
71 participants, comprising 26 patients with nonobstructive hypertrophic cardiomyopathy and 45 healthy subjects.
E
Exposure / Comparator
Hypertrophic cardiomyopathy vs Healthy subjects
O
Primary Outcome
Average longitudinal strain, p=<0.001
Main Result
Absolute Event Rate: -15.1% vs -20.3%
p-value: p=<0.001
Cite This Study
Serri et al. (2006) conducted a case-control in Hypertrophic cardiomyopathy (n=71). Hypertrophic cardiomyopathy vs. Healthy subjects was evaluated on Average longitudinal strain (p=<0.001). Two-dimensional strain echocardiography identified significantly reduced average longitudinal strain in patients with hypertrophic cardiomyopathy compared to healthy controls (-15.1% vs -20.3%, p<0.001).