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This research investigates the inhibition of iron uptake through targeted interference with the transferrin receptor.

July 29, 2026Scientific ReportsOpen Access

A small lipidated peptide that inhibits transferrin uptake

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Randomized trial demonstrates inhibition of transferrin uptake in cancer cells, suggesting a novel therapeutic strategy.

This research investigates the inhibition of iron uptake through targeted interference with the transferrin receptor.
Utilized fluorescently labeled transferrin to analyze cellular endocytosis.
Employed lipidated decoy peptides that bind to endocytic motifs recognized by the AP2 complex.
Evaluated the inhibition efficacy of peptides targeting AP2 mu and sigma subunits.
Transferrin endocytosis decreased in the presence of the peptide targeting the mu subunit.
No inhibition of transferrin endocytosis was observed with the peptide targeting the sigma subunit.
Indicates the potential of selective inhibition of the AP2 mu subunit to block iron influx in cancer cells.

Nicosia et al. (2026) studied this question.

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