This review updates regulatory mechanisms of calcium sensitization in gastrointestinal smooth muscles, suggesting new treatments for motility disorders.
) cells form the SIP syncytium, which regulates excitability and calcium sensitization. This review updates our current understanding of the regulatory mechanisms of calcium sensitization with the recent findings from genetically engineered mice with deficiencies in protein kinase C and ROCK2 calcium sensitization pathways, and the involvement of interstitial cells in regulating GI smooth muscle cell excitability. Dysregulated calcium sensitization pathways in motility disorders are summarized, to potentially aid in the development of new pharmacological strategies to prevent and treat GI motility disorders.
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Perrino et al. (2026) studied this question.
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