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July 29, 2026LifeOpen Access

Lamotrigine-Induced Toxic Epidermal Necrolysis with Multiorgan Failure, Pneumatosis Intestinalis and Chronic Ocular Complications

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Authors

JSJakub SzramaPSPiotr SmuszkiewiczAWAmadeusz Woźniak

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Overview

Case report documents severe lamotrigine-induced TEN with multiorgan failure, highlighting the need for intensive care and long-term follow-up.

Key Points

  • The case aims to illustrate the severe effects of lamotrigine-induced toxic epidermal necrolysis and its complications.
  • Patient presented with severe TEN requiring ICU admission and mechanical ventilation.
  • Treatment included high-dose intravenous methylprednisolone, immunoglobulins, and plasmapheresis.
  • Narrative review synthesized literature on diagnosis, management, and complications of TEN.
  • Patient developed gastrointestinal complications, including pneumatosis intestinalis and portal venous gas.
  • Complete resolution of cutaneous lesions occurred, but persistent ocular complications developed.
  • Ocular issues required ongoing ophthalmological care due to complications like meibomian gland dysfunction and corneal neovascularization.

Cite This Study

Szrama et al. (2026) studied this question.

synapsesocial.com/papers/6a69a28ac8da07d9defa60d7https://doi.org/10.3390/life16081238
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Toxic Epidermal Necrolysis by Lamotrigine - A Case Report of Fatality2024
  2. 2Toxic Epidermal Necrolysis: Case Report and Review2024
  3. 3Antimicrobial toxic epidermal necrolysis in an ICU patient with multisystem organ failure and sepsis2026 · 1 citations
  4. 4Early Recognition and Management of Ocular Manifestations of Toxic Epidermal Necrolysis in a Pediatric Patient: A Case Report2024 · 2 citations
  5. 5Toxic epidermal necrolysis: lessons from three fatal cases2025