A ROS-Responsive Dual-Functional H ₂ S Donor for Synergistic Cardioprotection

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The aim is to evaluate the cardioprotective efficacy of a novel ROS-responsive H2S donor during myocardial ischemia-reperfusion injury (MIRI).
Developed a dual-functional H2S donor that is responsive to reactive oxygen species (ROS).
Assessed the therapeutic effects on cardioprotection in a model of MIRI.
Utilized various bioactive compounds to study their synergistic effects.
Demonstrated significant cardioprotective effects of the H2S donor in MIRI models.
Notably reduced ischemic injury metrics, indicating enhanced cardiac function post-reperfusion.

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Explores synergistic cardioprotection in MIRI with a novel H2S donor, suggesting therapeutic potential.

S and a bioactive β-carboline, thereby offering a promising therapeutic approach for MIRI.

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Zhang et al. (2026) studied this question.

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