High-Intensity Interval Training Ameliorates Oxidative Stress and Mitophagy in Heart Tissue of Healthy Rats Following the Combination Use of Methylphenidate and Ethanol

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Key Points

This study aims to investigate the impact of high-intensity interval training on cardiac outcomes related to combined methylphenidate and ethanol exposure in rats.
Male Wistar rats were assigned to receive saline, HIIT, methylphenidate, ethanol, or combinations of these treatments.
Cardiac tissue damage was assessed via staining techniques, and gene expression was quantified using Real-time PCR.
Levels of oxidative stress markers such as superoxide dismutase, glutathione peroxidase, and malondialdehyde were measured.
Combination of ethanol and methylphenidate significantly increased malondialdehyde levels (p<0.01) and decreased superoxide dismutase activity (p<0.05).
High-intensity interval training notably reduced oxidative stress and reversed mitochondrial fission and mitophagy indicators in treated groups.
HIIT led to decreased histopathological changes in the ethanol and methylphenidate combination groups.

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Investigates how HIIT affects oxidative stress in rat hearts exposed to methylphenidate and ethanol, suggesting potential protective benefits.

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Shirazpour et al. (2026) studied this question.

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