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July 29, 2026MetabolitesOpen Access

Metabolic Dysregulation in ADHD: Implications for Appetite, Sleep, Stress Reactivity, and Pharmacological Treatment

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Authors

DADavoud AmiriSSSwetang J ShahLBLamberto Briziarelli

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Overview

Review evaluates associations between ADHD and metabolic, inflammatory, and neuroendocrine dysfunction, suggesting broader implications.

Key Points

  • This review aims to link ADHD with hypothalamic inflammation and related metabolic and neuroendocrine dysregulation.
  • Conducted a systematic literature search in multiple databases until May 31, 2026.
  • Focused on human observational and intervention studies to form an evidence base.
  • Narratively synthesized evidence, summarizing quantitative findings from previous meta-analyses.
  • ADHD is associated with increased obesity risk and altered appetite-related hormones.
  • Evidence indicates immune-inflammatory changes and atypical cortisol responsivity.
  • Findings suggest hypothalamic and neuroendocrine mechanisms as plausible contributors in some ADHD individuals.

Cite This Study

Amiri et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2a3c8da07d9defa6597https://doi.org/10.3390/metabo16080527
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Also Consider

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  4. 4Association Between ADHD and Obesity: A Systematic Review and Meta-Analysis2015 · 613 citations
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