Demonstrates efficient formation of enamine naphthalenones, indicating broad applicability across various substrates.
annulation of 2-bromoaryl enaminones with terminal alkynes proceeding via Cu(III)-acetylide intermediates affords enamine naphthalenones in up to 94% yield, featuring broad substrate scope and good functional group tolerance. Amine exchange enables the modular incorporation of aniline and diverse secondary amines, significantly expanding molecular diversity.
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Li et al. (2026) studied this question.
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