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July 29, 2026BMC CancerOpen Access

Impact of sarcopenia on short- and long-term outcomes after resection of perihilar cholangiocarcinoma: a two-center study

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Authors

XWXingbo WeiHHHaiyang HuSLShipeng Li

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Overview

Retrospective study evaluates sarcopenia's predictive value for postoperative outcomes in pCCA, indicating its significance.

Key Points

  • This study aimed to assess the impact of sarcopenia on postoperative outcomes in patients undergoing resection for perihilar cholangiocarcinoma.
  • Retrospective analysis of 271 pCCA patients undergoing surgical resection from 2016 to 2021.
  • Patients classified into training and validation cohorts at a 7:3 ratio.
  • Logistic regression and Cox proportional hazards regression analyzed the relationship between sarcopenia and postoperative outcomes.
  • 144 (53.1%) patients were diagnosed with sarcopenia, leading to significantly higher rates of postoperative complications.
  • Independent risk factors for overall survival include BMI (p=0.026), performance status (p<0.001), R1 surgical margins (p<0.001), and presence of sarcopenia (p<0.001).
  • A nomogram predicting overall survival was developed with AUC greater than 0.8, demonstrating strong predictive performance.

Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2aec8da07d9defa664bhttps://doi.org/10.1186/s12885-026-16305-7
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  5. 5Effect of preoperative body composition on long-term outcomes in patients undergoing distal cholangiocarcinoma resection2026