What question did this study set out to answer?

This trial aims to assess the impact of gradual versus abrupt withdrawal of semaglutide on weight and cardiometabolic health in individuals with obesity.

July 29, 2026PLoS ONEOpen Access

Impact of semaglutide withdrawal on cardiometabolic profile and physiology of energy balance: Recovery effects after semaglutide termination – The REST trial study protocol

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Authors

TYTaras YevusiakMount Sinai Hospital AWAlanna WeismanMount Sinai Hospital RRRavi RetnakaranMount Sinai Hospital

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Implication

Randomized trial examines weight and cardiometabolic outcomes after gradual vs. abrupt semaglutide cessation in individuals living with obesity, indicating treatment strategies for long-term...

Key Points

This trial aims to assess the impact of gradual versus abrupt withdrawal of semaglutide on weight and cardiometabolic health in individuals with obesity.
Randomized controlled trial comparing gradual dose reduction to abrupt cessation of semaglutide.
Participants: Adults living with obesity, achieving 10% weight loss on semaglutide, without preexisting cardiovascular disease.
Primary outcome: Body weight change (%) between groups; secondary outcomes: 24-hour ambulatory blood pressure and fasting ghrelin levels.
Hypothesized gradual reduction will lead to less weight regain compared to abrupt cessation.
Expected improvement in cardiometabolic profile associated with gradual tapering of semaglutide.
Trial registration identifier: NCT07294950.

Cite This Study

Yevusiak et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2aec8da07d9defa66a4 https://doi.org/10.1371/journal.pone.0354237

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Implication

Randomized trial examines weight and cardiometabolic outcomes after gradual vs. abrupt semaglutide cessation in individuals living with obesity, indicating treatment strategies for long-term...

Impact of semaglutide withdrawal on cardiometabolic profile and physiology of energy balance: Recovery effects after semaglutide termination – The REST trial study protocol

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of semaglutide withdrawal on cardiometabolic profile and physiology of energy balance: Recovery effects after semaglutide termination – The REST trial study protocol

Discussion

Member takes

Implication

Key Points

Cite This Study

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